Real-world efficacy of daclatasvir and asunaprevir with respect to resistance-associated substitutions
نویسندگان
چکیده
منابع مشابه
Real-world efficacy of daclatasvir and asunaprevir with respect to resistance-associated substitutions
AIM To investigate daclatasvir (DCV) and asunaprevir (ASV) efficacy in hepatitis C (HCV) patients, with respect to resistance-associated substitutions (RASs). METHODS A total of 392 HCV-infected patients from multiple centers were included in this study. We evaluated their clinical courses and sustained virologic responses (SVR) according to pretreatment factors (gender, age, history of inter...
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15 صفحه اولComplex Pattern of Resistance-Associated Substitutions of Hepatitis C Virus after Daclatasvir/Asunaprevir Treatment Failure
BACKGROUNDS & AIMS We aimed to clarify the characteristics of resistance-associated substitutions (RASs) after treatment failure with NS5A inhibitor, daclatasvir (DCV) in combination with NS3/4A inhibitor, asunaprevir (ASV), in patients with chronic hepatitis C virus genotype 1b infection. METHODS This is a nationwide multicenter study conducted by the Japanese Red Cross Liver Study Group. Th...
متن کاملThe Real-World Safety and Efficacy of Daclatasvir and Asunaprevir for Elderly Patients
Background/Aims Although daclatasvir with asunaprevir was approved in Japan for interferon ineligible or intolerant patients, patients aged ≥75 years were excluded in the phase III trial. The present study aimed to evaluate the safety and efficacy of this therapy for elderly patients aged ≥75 years and to clarify whether an extremely high sustained virological response (SVR) rate can be achieve...
متن کاملDaclatasvir plus Asunaprevir Treatment for Real-World HCV Genotype 1-Infected Patients in Japan
Background. All-oral combination of direct-acting antivirals could lead to higher sustained virologic response (SVR) in hepatitis C virus (HCV)-infected patients. In the present study, we examined the efficacy and safety of the dual oral treatment with HCV nonstructural protein (NS) 5A inhibitor daclatasvir (DCV) plus HCV NS3/4A inhibitor asunaprevir (ASV) for 24 weeks in real-world HCV genotyp...
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ژورنال
عنوان ژورنال: World Journal of Hepatology
سال: 2017
ISSN: 1948-5182
DOI: 10.4254/wjh.v9.i25.1064